Common structural and epigenetic changes in the genome of castration-resistant prostate cancer.

@article{Friedlander2012CommonSA,
  title={Common structural and epigenetic changes in the genome of castration-resistant prostate cancer.},
  author={Terence Friedlander and Ritu P. Roy and Scott Arthur Tomlins and Vy T. Ngo and Yasuko Kobayashi and Aruna Azameera and Mark A. Rubin and Kenneth J. Pienta and Arul M. Chinnaiyan and Michael Ittmann and Charles J. Ryan and Pamela L. Paris},
  journal={Cancer research},
  year={2012},
  volume={72 3},
  pages={616-25}
}
Progression of primary prostate cancer to castration-resistant prostate cancer (CRPC) is associated with numerous genetic and epigenetic alterations that are thought to promote survival at metastatic sites. In this study, we investigated gene copy number and CpG methylation status in CRPC to gain insight into specific pathophysiologic pathways that are… CONTINUE READING