Common statistical issues in genome-wide association studies: a review on power, data quality control, genotype calling and population structure

@article{Teo2008CommonSI,
  title={Common statistical issues in genome-wide association studies: a review on power, data quality control, genotype calling and population structure},
  author={Yik Ying Teo},
  journal={Current Opinion in Lipidology},
  year={2008},
  volume={19},
  pages={133–143}
}
  • Y. Teo
  • Published 1 April 2008
  • Biology
  • Current Opinion in Lipidology
Purpose of review Genetic association studies which survey the entire genome have become a common design for uncovering the genetic basis of common diseases, including lipid-related traits. Such studies have identified several novel loci which influence blood lipids. The present review highlights the statistical challenges associated with such large-scale genetic studies and discusses the available methodological strategies for handling these issues. Recent findings The successful analysis of… 
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