Common sodium channel promoter haplotype in asian subjects underlies variability in cardiac conduction.

@article{Bezzina2006CommonSC,
  title={Common sodium channel promoter haplotype in asian subjects underlies variability in cardiac conduction.},
  author={Connie R. Bezzina and Wataru Shimizu and Ping Yang and Tamara T. Koopmann and Michael W. T. Tanck and Yoshihiro Miyamoto and Shiro Kamakura and Dan M. Roden and Arthur A. M. Wilde},
  journal={Circulation},
  year={2006},
  volume={113 3},
  pages={338-44}
}
BACKGROUND Reduced cardiac sodium current slows conduction and renders the heart susceptible to ventricular fibrillation. Loss of function mutations in SCN5A, encoding the cardiac sodium channel, are one cause of the Brugada syndrome, associated with slow conduction and a high incidence of ventricular fibrillation, especially in Asians. In this study, we… CONTINUE READING