Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes.

@article{Sorensen2003CommonSP,
  title={Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes.},
  author={Scott D. Sorensen and Olivier Nicole and Richard D Peavy and Lisa M Montoya and C Justin Lee and T. J. Murphy and Stephen F Traynelis and John R Hepler},
  journal={Molecular pharmacology},
  year={2003},
  volume={64 5},
  pages={1199-209}
}
Receptors for the serine protease thrombin and for lysophospholipids are coupled to G proteins and control a wide range of cellular functions, including mitogenesis. Activators of these receptors are present in blood, and can enter the brain during central nervous system (CNS) injury. Reactive astrogliosis, a prominent component of CNS injury with potentially harmful consequences, may involve proliferation of astrocytes. In this study, we have examined the expression and activation of protease… CONTINUE READING
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Lysophospholipid receptors

  • N Fukushima, I Ishii, Contos JJA, JA Weiner, J Chun
  • Ann Rev Pharmacol Toxicol
  • 2001
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