Common sequence variants on 20q11.22 confer melanoma susceptibility

  title={Common sequence variants on 20q11.22 confer melanoma susceptibility},
  author={Kevin M Brown and Stuart Macgregor and Grant W. Montgomery and David W. Craig and Zhen Zhen Zhao and Kelly R Iyadurai and Anjali K. Henders and Nils Homer and Megan E. J. Campbell and Mitchell Stark and Shane Thomas and Helen Schmid and Elizabeth A. Holland and Elizabeth Gillanders and David L Duffy and Judith A. Maskiell and Jodie Jetann and Megan M Ferguson and Dietrich A. Stephan and Anne E Cust and David B Whiteman and Ad{\`e}le Green and H{\aa}kan Olsson and Susana Puig and Paola Ghiorzo and Johan Hansson and Florence Demenais and Alisa M. Goldstein and Nelleke A. Gruis and David E. Elder and Julia A. Newton Bishop and Richard F. Kefford and Graham G. Giles and Bruce Konrad Armstrong and Joanne F Aitken and John L. Hopper and Nicholas G. Martin and Jeffrey M. Trent and Graham J. Mann and N. K. Hayward},
  journal={Nature Genetics},
We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 × 10−15). The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases.