Common risk allele in aromatic antiepileptic-drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Han Chinese.

@article{Hung2010CommonRA,
  title={Common risk allele in aromatic antiepileptic-drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Han Chinese.},
  author={Shuen-Iu Hung and Wen-Hung Chung and Zhi-sheng Liu and C Chen and Mo-Song Hsih and Rosaline Chung-yee Hui and Chia-Yu Chu and Yuan-Tsong Chen},
  journal={Pharmacogenomics},
  year={2010},
  volume={11 3},
  pages={349-56}
}
AIMS Compared with other categories of drugs, such as antibiotics and NSAIDs, antiepileptic therapies are associated with a high incidence of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). We previously reported that carbamazepine (CBZ)-SJS/TEN is strongly associated with the HLA-B*1502 in Han Chinese, which has been confirmed in other Southeast Asian countries where the allele is prevalent. Here, we extend the study of HLA susceptibility to three different antiepileptic… CONTINUE READING
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