Common resting brain dynamics indicate a possible mechanism underlying zolpidem response in severe brain injury

@inproceedings{Williams2013CommonRB,
  title={Common resting brain dynamics indicate a possible mechanism underlying zolpidem response in severe brain injury},
  author={Shawniqua T Williams and Mary M. Conte and Andrew M Goldfine and Quentin Noirhomme and Olivia Gosseries and Marie Thonnard and Bradley Beattie and Jennifer E Hersh and Douglas I. Katz and Jonathan D. Victor and Steven Laureys and Nicholas D. Schiff},
  booktitle={eLife},
  year={2013}
}
Zolpidem produces paradoxical recovery of speech, cognitive and motor functions in select subjects with severe brain injury but underlying mechanisms remain unknown. In three diverse patients with known zolpidem responses we identify a distinctive pattern of EEG dynamics that suggests a mechanistic model. In the absence of zolpidem, all subjects show a strong low frequency oscillatory peak ∼6-10 Hz in the EEG power spectrum most prominent over frontocentral regions and with high coherence (∼0.7… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 17 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 31 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 48 references

Drug induced arousal from the permanent vegetative state.

NeuroRehabilitation • 2006
View 4 Excerpts
Highly Influenced

Thalamocortical dysrhythmia: A neurological and neuropsychiatric syndrome characterized by magnetoencephalography.

Proceedings of the National Academy of Sciences of the United States of America • 1999
View 6 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…