Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease

  title={Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease},
  author={Themistocles L. Assimes and Joshua W. Knowles and James Rush Priest and Analabha Basu and Kelly A. Volcik and Audrey Southwick and Holly K Tabor and Jaana A. Hartiala and Hooman Allayee and Megan L. Grove and Raymond Tabibiazar and Stephen Sidney and Stephen P. Fortmann and Alan S. Go and Mark A. Hlatky and Carlos Iribarren and Eric Boerwinkle and Richard M. Myers and Neil J. Risch and Thomas Quertermous},
  journal={Human Genetics},
Recent human genetic studies suggest that allelic variants of leukotriene pathway genes influence the risk of clinical and subclinical atherosclerosis. We sequenced the promoter, exonic, and splice site regions of ALOX5 and ALOX5AP and then genotyped 7 SNPs in ALOX5 and 6 SNPs in ALOX5AP in 1,552 cases with clinically significant coronary artery disease (CAD) and 1,583 controls from Kaiser Permanente including a subset of participants of the coronary artery risk development in young adults… CONTINUE READING


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