Common polymorphisms in the microsomal epoxide hydrolase and N-acetyltransferase 2 genes in association with inflammatory bowel disease in the Danish population.

@article{Ernst2011CommonPI,
  title={Common polymorphisms in the microsomal epoxide hydrolase and N-acetyltransferase 2 genes in association with inflammatory bowel disease in the Danish population.},
  author={Anja Ernst and Vibeke Andersen and Mikkel Ǿstergaard and Bent Ascanius Jacobsen and Inge S{\o}kilde Pedersen and Asbj{\o}rn Mohr Drewes and Henrik Okkels and Henrik B Krarup},
  journal={European journal of gastroenterology & hepatology},
  year={2011},
  volume={23 3},
  pages={
          269-74
        }
}
INTRODUCTION Chronic inflammatory bowel disease (IBD) is characterized by recurrent inflammation of the intestinal mucosa. Reactive molecules play a central role in altering the intestinal permeability, which may induce or sustain an immune response. Changes in detoxification of substances that causes epithelial damage may confer susceptibility to IBD. Hence, polymorphic enzymes involved in the detoxification processes may be risk factors of IBD. METHODS The two biotransformation enzymes… CONTINUE READING
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