Common polymorphisms in methylenetetrahydrofolate reductase gene are associated with risks of cervical intraepithelial neoplasia and cervical cancer in women with low serum folate and vitamin B12

@article{Tong2010CommonPI,
  title={Common polymorphisms in methylenetetrahydrofolate reductase gene are associated with risks of cervical intraepithelial neoplasia and cervical cancer in women with low serum folate and vitamin B12},
  author={Seo-yun Tong and Mi Kyung Kim and Jae Kwan Lee and Jong Min Lee and Sang Woon Choi and Simonetta Friso and Eun-Seop Song and Kwang Beom Lee and Jung Pil Lee},
  journal={Cancer Causes & Control},
  year={2010},
  volume={22},
  pages={63-72}
}
We evaluated associations between folate, vitamin B12, and the methylenetetrahydrofolate reductase (MTHFR) gene, and risk of cervical intraepithelial neoplasia (CIN) and cervical cancer. This multicenter case–control study enrolled 927 Korean women (440 controls, 165 patients with CIN 1, 167 patients with CIN 2/3, and 155 patients with cervical cancer, aged 20–75 years). Patients with cervical cancer had significantly lower median serum folate and vitamin B12 concentrations vs. controls. Higher… CONTINUE READING