Common polymorphism in H19 associated with birthweight and cord blood IGF-II levels in humans

@article{Petry2004CommonPI,
  title={Common polymorphism in H19 associated with birthweight and cord blood IGF-II levels in humans},
  author={Clive J Petry and Ken K Ong and Bryan J. Barratt and Diane L Wingate and Heather J. Cordell and Susan M. Ring and Marcus E. Pembrey and Wolf Reik and John A. Todd and David B Dunger},
  journal={BMC Genetics},
  year={2004},
  volume={6},
  pages={22 - 22}
}
Common genetic variation at genes that are imprinted and exclusively maternally expressed could explain the apparent maternal-specific inheritance of low birthweight reported in large family pedigrees. We identified ten single nucleotide polymorphisms (SNPs) in H19, and we genotyped three of these SNPs in families from the contemporary ALSPAC UK birth cohort (1,696 children, 822 mothers and 661 fathers) in order to explore associations with size at birth and cord blood IGF-II levels. Both… CONTINUE READING