Common polygenic variation contributes to risk of migraine in the Norfolk Island population

@article{RodriguezAcevedo2015CommonPV,
  title={Common polygenic variation contributes to risk of migraine in the Norfolk Island population},
  author={Astrid J. Rodriguez-Acevedo and Manuel A Ferreira and Miles C Benton and Melanie A. Carless and Harald H H Goring and Joanne E. Curran and John Blangero and Rodney Arthur Lea and Lyn R Griffiths},
  journal={Human Genetics},
  year={2015},
  volume={134},
  pages={1079-1087}
}
Migraine has been defined as a common disabling primary headache disorder. Epidemiology studies have provided with the undeniable evidence of genetic components as active players in the development of the disease under a polygenic model in which multiple risk alleles exert modest individual effects. Our objective was to test the contribution of a polygenic effect to migraine risk in the Norfolk Island population using a panel of SNPs reported to be disease associated in published migraine GWAS… CONTINUE READING
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