Common pathways in idiopathic pulmonary fibrosis and cancer.

  title={Common pathways in idiopathic pulmonary fibrosis and cancer.},
  author={Carlo Vancheri},
  journal={European respiratory review : an official journal of the European Respiratory Society},
  volume={22 129},
Idiopathic pulmonary fibrosis (IPF) is marked by a very disappointing survival rate and still represents a clinical dilemma. According to the current pathogenic hypothesis, chronic damage of the alveolar epithelium is followed by abnormal tissue repair and impairment of the alveolar structure. This process is driven by pathogenic events very similar to cancer, including epigenetic and genetic changes, altered response to regulatory signals, abnormal expression of microRNAs and activation of… CONTINUE READING

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