Common pathophysiologic mechanisms in migraine and epilepsy.

  title={Common pathophysiologic mechanisms in migraine and epilepsy.},
  author={Michael A Rogawski},
  journal={Archives of neurology},
  volume={65 6},
Migraine and epilepsy are comorbid episodic disorders that have common pathophysiologic mechanisms. Migraine attacks, like epileptic seizures, may be triggered by excessive neocortical cellular excitability; in migraine, however, the hyperexcitability is believed to transition to cortical spreading depression rather than to the hypersynchronous activity that characterizes seizures. Some forms of epilepsy and migraine are known to be channelopathies. Mutations in the same genes can cause either… CONTINUE READING


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