Common origin of the I1307K APC polymorphism in Ashkenazi and non-Ashkenazi Jews

@article{Patael1999CommonOO,
  title={Common origin of the I1307K APC polymorphism in Ashkenazi and non-Ashkenazi Jews},
  author={Yael Patael and Ari{\'e} Figer and Ruth Gershoni-baruch and Moshe Zvi Papa and Shulamit Risel and Rakefet Shtoyerman-Chen and Avraham Karasik and Livia Theodor and Eitan A. Friedman},
  journal={European Journal of Human Genetics},
  year={1999},
  volume={7},
  pages={555-559}
}
A common germline missense mutation within the APC gene, I1307K, has recently been described in Ashkenazi Jews. We detected this polymorphism in two non-Ashkenazi Jewish women using denaturing gradient gel electrophoresis (DGGE), and hypothesized that in Jewish individuals it might not be restricted to Ashkenazim, and actually reflect a common ancestral polymorphism. To test this notion we performed allelic pattern determination using APC-linked markers in these two women and in nine Ashkenazi… CONTINUE READING
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