Common mitochondrial DNA and POLG1 mutations are rare in the Chinese patients with adult-onset ataxia on Taiwan.

@article{Lee2007CommonMD,
  title={Common mitochondrial DNA and POLG1 mutations are rare in the Chinese patients with adult-onset ataxia on Taiwan.},
  author={Yi-Chung Lee and Yi-chun Lu and M Chang and Bing-Wen Soong},
  journal={Journal of the neurological sciences},
  year={2007},
  volume={254 1-2},
  pages={65-8}
}
BACKGROUND AND PURPOSE Spinocerebellar ataxia (SCA) is a heterogeneous group of neurodegenerative disorders with common features of adult-onset cerebellar ataxia. Many patients with clinically suspected SCA are subsequently diagnosed with common SCA gene mutations. Previous reports suggest some common mitochondrial DNA (mtDNA) point mutations and mitochondrial DNA polymerase gene (POLG1) mutations might be additional underlying genetic causes of cerebellar ataxia. We tested whether mtDNA point… CONTINUE READING