Common gynecological challenges in adolescents with sickle cell disease

@article{Stimpson2016CommonGC,
  title={Common gynecological challenges in adolescents with sickle cell disease},
  author={Sarah-Jo Stimpson and Erin C. Rebele and Michael Rutledge DeBaun},
  journal={Expert Review of Hematology},
  year={2016},
  volume={9},
  pages={187 - 196}
}
ABSTRACT Sickle cell anemia is one of the most common genetic blood disorders worldwide. Individuals with sickle cell disease (SCD) experience clinical manifestations such as chronic anemia, developmental delay, vaso-occlusive pain, acute chest syndrome, and neurological complications. Adolescent girls with SCD face unique gynecological challenges including delayed puberty marked by a later onset in menarche, vaso-occlusive pain associated with their menstrual cycle, and underdiagnosed abnormal… 

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References

SHOWING 1-10 OF 79 REFERENCES

Painful Crises and Menstruation in Sickle Cell Disease

The data indicated that those patients who had sickle cell crises were significantly older and had been menstruating longer, with heavier periods, pointing to the onset of menstruation as a possible precipitant of painful crises in some women with sicklecell disease.

The painful crisis of homozygous sickle cell disease: clinical features

Fever was common even in apparently uncomplicated painful crises, suggesting that fever is characteristic of the painful crisis itself and not necessarily indicative of infection.

Gynaecological and obstetric management of women with inherited bleeding disorders

  • C. DemersC. DerzkoM. DavidJ. Douglas
  • Medicine
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
  • 2006

Menstrual disorders in adolescence.

  • G. Slap
  • Medicine
    Best practice & research. Clinical obstetrics & gynaecology
  • 2003
An approach to adolescent amenorrhoea is presented that utilizes primary versus secondary amenor rhoea, delayed versus normal pubertal development, and the presence or absence of hyperandrogenism as nodal points for decision making.

Menstrual pattern in women with sickle cell anaemia and its association with sickling crises.

  • W. YoongS. Tuck
  • Medicine
    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
  • 2002
Evaluating the natural menstrual pattern in women with sickle cell anaemia found that 58% of women had some form of cyclical crises (albeit not severe) in association with menstrual cycles, and the use of a continuous combined contraceptive pill regime or Depo-Provera to induce amenorrhoea should be considered.

The painful crisis of homozygous sickle cell disease. A study of the risk factors.

There was a striking increase in painful crises in male patients between the ages of 15 and 25 years, whereas female patients showed little age-related change, and high hemoglobin levels appear to be an important risk factor for painful crises.

Daily Assessment of Pain in Adults with Sickle Cell Disease

The relationship among self-reported pain, crises, and health care utilization for pain in a cohort study of patients with sickle cell disease was examined, with particular emphasis on potentially mutable, causal, nonbiological variables.

Norplant® use by women with sickle cell disease

Current issues in sickle cell pain and its management.

  • S. Ballas
  • Medicine
    Hematology. American Society of Hematology. Education Program
  • 2007
Management of sickle pain is primarily pharmacologic in nature, and opioids are the analgesics used most often, and Cellular and molecular mechanisms of opioids explain individual differences among patients and justify the use of individualized treatment plans.
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