Common gynecological challenges in adolescents with sickle cell disease

  title={Common gynecological challenges in adolescents with sickle cell disease},
  author={Sarah-Jo Stimpson and Erin C. Rebele and Michael Rutledge DeBaun},
  journal={Expert Review of Hematology},
  pages={187 - 196}
ABSTRACT Sickle cell anemia is one of the most common genetic blood disorders worldwide. Individuals with sickle cell disease (SCD) experience clinical manifestations such as chronic anemia, developmental delay, vaso-occlusive pain, acute chest syndrome, and neurological complications. Adolescent girls with SCD face unique gynecological challenges including delayed puberty marked by a later onset in menarche, vaso-occlusive pain associated with their menstrual cycle, and underdiagnosed abnormal… 

Heavy Menstrual Bleeding in Adolescent: Normal or a Sign of an Underlying Disease?

First-line treatment of HMB among adolescents is medical management with hormonal therapy or nonhormonal options, and Levonorgestrel-releasing intrauterine device is an effective tool also for all adolescents with menstrual needs.

Sexual health of French adolescents with sickle cell disease

  • Marion GrosC. Jung Adèle Carlier-Gonod
  • Medicine, Psychology
    The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception
  • 2020
Clinicians caring for teenagers followed for SCD should be aware of the need for sexual health information in order to propose prevention actions adapted to these young people with chronic disease.

Ovarian reserve in nigerian women with sickle cell anaemia: a cross- sectional study

The study showed diminished ovarian reserve in women with HbSS when compared to age-matched women withHbAA, and a significant negative correlation was found between serum AMH and BMI in womenwith HbAA.

Mouse Models of Pain in Sickle Cell Disease

Humanized transgenic mice expressing exclusively human sickle hemoglobin show features of pain and pathobiology similar to that in patients with SCD, which offer the potential for investigating the mechanisms of pain in SCD and allow for development of novel targeted analgesic therapies.

Knowledge insufficient: the management of haemoglobin SC disease

Clinical and translational research is needed to develop targeted treatments and to validate management recommendations for efficacy, safety and impact on quality of life for people with HbSC.

Efficacy of the Nutritional Supplement, EvenFlo, in the Management of Sickle Cell Disease: A Randomized Controlled Trial

EvenFlo is a nutraceutical supplement effective in the management of SCD when combined with folic acid; its beneficial effect would be useful in boosting the hemoglobin concentration and weight indices individuals with SCD as well as and in limiting the crises they suffered.

Effect of chronic opioid therapy on pain and survival in a humanized mouse model of sickle cell disease.

Chronic morphine treatment leads to decreased survival in control mice, but not in sickle mice, and chronic morphine treatment does not lead to analgesic tolerance.



Painful Crises and Menstruation in Sickle Cell Disease

The data indicated that those patients who had sickle cell crises were significantly older and had been menstruating longer, with heavier periods, pointing to the onset of menstruation as a possible precipitant of painful crises in some women with sicklecell disease.

The painful crisis of homozygous sickle cell disease: clinical features

Fever was common even in apparently uncomplicated painful crises, suggesting that fever is characteristic of the painful crisis itself and not necessarily indicative of infection.

Gynaecological and obstetric management of women with inherited bleeding disorders

  • C. DemersC. DerzkoM. DavidJ. Douglas
  • Medicine
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
  • 2006

Menstrual disorders in adolescence.

  • G. Slap
  • Medicine
    Best practice & research. Clinical obstetrics & gynaecology
  • 2003
An approach to adolescent amenorrhoea is presented that utilizes primary versus secondary amenor rhoea, delayed versus normal pubertal development, and the presence or absence of hyperandrogenism as nodal points for decision making.

Menstrual pattern in women with sickle cell anaemia and its association with sickling crises.

  • W. YoongS. Tuck
  • Medicine
    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
  • 2002
Evaluating the natural menstrual pattern in women with sickle cell anaemia found that 58% of women had some form of cyclical crises (albeit not severe) in association with menstrual cycles, and the use of a continuous combined contraceptive pill regime or Depo-Provera to induce amenorrhoea should be considered.

The painful crisis of homozygous sickle cell disease. A study of the risk factors.

There was a striking increase in painful crises in male patients between the ages of 15 and 25 years, whereas female patients showed little age-related change, and high hemoglobin levels appear to be an important risk factor for painful crises.

Daily Assessment of Pain in Adults with Sickle Cell Disease

The relationship among self-reported pain, crises, and health care utilization for pain in a cohort study of patients with sickle cell disease was examined, with particular emphasis on potentially mutable, causal, nonbiological variables.

Norplant® use by women with sickle cell disease

Current issues in sickle cell pain and its management.

  • S. Ballas
  • Medicine
    Hematology. American Society of Hematology. Education Program
  • 2007
Management of sickle pain is primarily pharmacologic in nature, and opioids are the analgesics used most often, and Cellular and molecular mechanisms of opioids explain individual differences among patients and justify the use of individualized treatment plans.