Common genetic variation within IGFI, IGFII, IGFBP-1, and IGFBP-3 and endometrial cancer risk.

@article{McGrath2011CommonGV,
  title={Common genetic variation within IGFI, IGFII, IGFBP-1, and IGFBP-3 and endometrial cancer risk.},
  author={Monica B McGrath and I. -T. Lee and Julie E. Buring and Immaculata de Vivo},
  journal={Gynecologic oncology},
  year={2011},
  volume={120 2},
  pages={174-8}
}
OBJECTIVE The insulin-like growth factor (IGF) pathway plays a critical role in the growth and development of the uterus and is believed to function as a mediator of steroid hormone actions in the endometrium. The local expression of genes encoding IGFs and IGF-binding proteins (IGFBPs) is important in determining IGF bioactivity in the uterus. Genetic variation in key genes within the IGF pathway may influence the rate of cellular proliferation and differentiation in the uterus and ultimately… CONTINUE READING