Common genetic variation in the ATP-binding cassette transporter A1, plasma lipids, and risk of coronary heart disease.

@article{Jensen2007CommonGV,
  title={Common genetic variation in the ATP-binding cassette transporter A1, plasma lipids, and risk of coronary heart disease.},
  author={Majken Karoline Jensen and Jennifer Pai and Kenneth Jay Mukamal and Kim Overvad and Eric B Rimm},
  journal={Atherosclerosis},
  year={2007},
  volume={195 1},
  pages={
          e172-80
        }
}
The ATP-binding cassette transporter A-1 (ABCA1) regulates cholesterol efflux from cells and is involved in high-density lipoprotein (HDL) metabolism and atherogenesis. We investigated whether common ABCA1 variants, previously reported to have phenotypic effects in humans, were associated with plasma lipids and CHD in a prospective study of coronary heart disease (CHD) in healthy women. Three polymorphisms in the promoter region (-565C/T, -191G/C, and -17C/G) and two in the coding region (I883M… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 17 CITATIONS

Similar Papers

Loading similar papers…