Common genetic variation in IGF1, IGFBP1 and IGFBP3 and ovarian cancer risk.

@article{Terry2009CommonGV,
  title={Common genetic variation in IGF1, IGFBP1 and IGFBP3 and ovarian cancer risk.},
  author={Kathryn L. Terry and Shelley S Tworoger and Margaret A. Gates and Daniel W Cramer and Susan E. Hankinson},
  journal={Carcinogenesis},
  year={2009},
  volume={30 12},
  pages={2042-6}
}
Insulin-like growth factor (IGF) 1 and its binding proteins foster cellular proliferation and inhibit apoptosis. In vitro studies show that IGF1 increases ovarian cell growth and invasive potential, suggesting a role for the IGF1 pathway in ovarian cancer etiology. We evaluated genetic variation in the IGF1, IGFBP1 and IGFBP3 genes in relation to ovarian cancer risk by genotyping 29 haplotype-tagging single nucleotide polymorphisms in 1173 cases and 1201 controls from the New England Case… CONTINUE READING