Common genetic variants of the BMP4, BMPR1A, BMPR1B, and ACVR1 genes, left ventricular mass, and other parameters of the heart in newborns.

@article{Gorcy2012CommonGV,
  title={Common genetic variants of the BMP4, BMPR1A, BMPR1B, and ACVR1 genes, left ventricular mass, and other parameters of the heart in newborns.},
  author={Iwona Gorący and Krzysztof Safranow and Grażyna Dawid and Karolina Skonieczna-Żydecka and Mariusz Kaczmarczyk and Jarosław Gorący and Beata Loniewska and Andrzej Ciechanowicz},
  journal={Genetic testing and molecular biomarkers},
  year={2012},
  volume={16 11},
  pages={1309-16}
}
The members of the family of bone morphogenetic proteins (BMPs) are important regulators in cardiac development. The present study was designed to evaluate the effect of common genetic variants of BMP-4 and its receptors BMPR1A, BMPR1B, and ACVR1 on left ventricular mass (LVM) and other parameters of the heart and blood pressure in newborns. The study included 210 healthy newborns. Two-dimensional M-mode echocardiography was used to assess LVM between days 3 and 4 after birth. Polymorphisms… CONTINUE READING