Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk.

Abstract

We mapped a high-penetrance gene (CRAC1; also known as HMPS) associated with colorectal cancer (CRC) in the Ashkenazi population to a 0.6-Mb region on chromosome 15 containing SCG5 (also known as SGNE1), GREM1 and FMN1. We hypothesized that the CRAC1 locus harbored low-penetrance variants that increased CRC risk in the general population. In a large series of colorectal cancer cases and controls, SNPs near GREM1 and SCG5 were strongly associated with increased CRC risk (for rs4779584, P = 4.44 x 10(-14)).

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@article{Jaeger2008CommonGV, title={Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk.}, author={Emma E. M. Jaeger and Emily L. Webb and Kimberley M. Howarth and Luis G. Carvajal-Carmona and Andrew Rowan and Peter Broderick and Axel Walther and Sarah L Spain and Alan M. Pittman and Zoe E Kemp and Kate Sullivan and Karl Heinimann and Steven J. Lubbe and Enric Domingo and Ella Barclay and Lynn Martin and Maggie Gorman and Ian P Chandler and Jayaram Vijayakrishnan and Wendy Wood and Elli Papaemmanuil and Steven Penegar and Mobshra Qureshi and Susan Mary Farrington and A. Tenesa and Jean-Baptiste Cazier and David James Kerr and Richard Gray and Julian Peto and Malcolm G. Dunlop and Harry Campbell and Huw JM Thomas and Richard S. Houlston and Ian Tomlinson}, journal={Nature genetics}, year={2008}, volume={40 1}, pages={26-8} }