Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk

Abstract

We mapped a high-penetrance gene (CRAC1; also known as HMPS) associated with colorectal cancer (CRC) in the Ashkenazi population to a 0.6-Mb region on chromosome 15 containing SCG5 (also known as SGNE1), GREM1 and FMN1. We hypothesized that the CRAC1 locus harbored low-penetrance variants that increased CRC risk in the general population. In a large series… (More)
DOI: 10.1038/ng.2007.41

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@article{Jaeger2008CommonGV, title={Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk}, author={Emma E. M. Jaeger and Emily L. Webb and Kimberley M. Howarth and Luis G Carvajal-Carmona and Andrew Rowan and Peter Broderick and A. Walther and Sarah Spain and Alan Pittman and Z. P. Kemp and Kate Sullivan and Karl Heinimann and Steven J. Lubbe and Enric Domingo and Ella Barclay and Lynn Pauline Martin and Maggie Gorman and I. D. Chandler and Jayaram Vijayakrishnan and Wendy Wood and Elli Papaemmanuil and Steven Penegar and M. Anwar Qureshi and Susan M Farrington and A. Tenesa and Jean-Baptiste Cazier and David Kerr and Richard Gray and Julian Peto and Malcolm Dunlop and Harry Campbell and Huw M. Thomas and Richard S. Houlston and Ian Tomlinson}, journal={Nature Genetics}, year={2008}, volume={40}, pages={26-28} }