Common genetic variants associated with breast cancer and mammographic density measures that predict disease.

@article{Odefrey2010CommonGV,
  title={Common genetic variants associated with breast cancer and mammographic density measures that predict disease.},
  author={Fabrice A. Odefrey and Jennifer Stone and Lyle C. Gurrin and Graham B. Byrnes and Carmel Apicella and Gillian S. Dite and Jennifer N Cawson and Graham G. Giles and Susan A. Treloar and Dallas English and John L. Hopper and Melissa C. Southey},
  journal={Cancer research},
  year={2010},
  volume={70 4},
  pages={1449-58}
}
Mammographic density for age and body mass index (BMI) is a heritable risk factor for breast cancer. We aimed to determine if recently identified common variants associated with small gradients in breast cancer risk are associated with mammographic density. We genotyped 497 monozygotic and 330 dizygotic twin pairs and 634 of their sisters from 903 families for 12 independent variants. Mammographic dense area, percent dense area, and nondense area were measured by three observers using a… CONTINUE READING
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