Common genetic polymorphisms affect the human requirement for the nutrient choline.

@article{Costa2006CommonGP,
  title={Common genetic polymorphisms affect the human requirement for the nutrient choline.},
  author={Kerry-Ann da Costa and Olga Kozyreva and Jiannan Song and Joseph Anton Galanko and Leslie M Fischer and Steven H Zeisel},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2006},
  volume={20 9},
  pages={1336-44}
}
Humans eating diets deficient in the essential nutrient choline can develop organ dysfunction. We hypothesized that common single nucleotide polymorphisms (SNPs) in genes involved in choline metabolism influence the dietary requirement of this nutrient. Fifty-seven humans were fed a low choline diet until they developed organ dysfunction or for up to 42 days. We tested DNA SNPs for allelic association with susceptibility to developing organ dysfunction associated with choline deficiency. We… CONTINUE READING
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