Common genetic determinants of vitamin D insufficiency: a genome-wide association study.

  title={Common genetic determinants of vitamin D insufficiency: a genome-wide association study.},
  author={Thomas J. Wang and Feng Zhang and J Brent Richards and Bryan R Kestenbaum and Joyce B. J. van Meurs and Diane Berry and Douglas P Kiel and Elizabeth A. Streeten and C Ohlsson and Daniel L. Koller and L. Peltonen and Jason. D Cooper and Paul F. O'Reilly and Denise K. Houston and Nicole L. Glazer and Liesbeth Vandenput and Munro Peacock and Julia M Shi and Fernando Rivadeneira and Mark I. McCarthy and Pouta Anneli and Ian H de Boer and Massimo Mangino and Bernet S. Kato and Deborah J. Smyth and Sarah L. Booth and Paul F Jacques and Greg L. Burke and Mark O Goodarzi and C Cheung and Myles Wolf and Kenneth Rice and David Goltzman and Nick Hidiroglou and Martin Ladouceur and Nicholas J Wareham and Lynne J. Hocking and Deborah Hart and Nigel K Arden and Cyrus Cooper and Suneil Malik and W. D. Fraser and A Hartikainen and Guangju Zhai and Helen M. Macdonald and Nita G Forouhi and Ruth J. F. Loos and David M. Reid and A. Nazrul Hakim and Elaine Dennison and Yongmei Liu and Chris Power and Helen E. Stevens and Laitinen Jaana and Ramachandran S. Vasan and Nicole Soranzo and Joerg Bojunga and Bruce M. Psaty and Mattias Lorentzon and Tatiana Foroud and Tamara B. Harris and Albert Hofman and John-Olov Jansson and Jane A. Cauley and Andr{\'e} G. Uitterlinden and Quince D. Gibson and Marjo-Riitta J{\"a}rvelin and David Karasik and David S Siscovick and Michael J. Econs and Stephen B. Kritchevsky and Jose C Florez and John A. Todd and Jos{\'e}e Dupuis and Elina Hypp{\"o}nen and Tim D. Spector},
  volume={376 9736},
BACKGROUND Vitamin D is crucial for maintenance of musculoskeletal health, and might also have a role in extraskeletal tissues. Determinants of circulating 25-hydroxyvitamin D concentrations include sun exposure and diet, but high heritability suggests that genetic factors could also play a part. We aimed to identify common genetic variants affecting vitamin D concentrations and risk of insufficiency. METHODS We undertook a genome-wide association study of 25-hydroxyvitamin D concentrations… CONTINUE READING
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