Common genetic determinants of the ataxic and hypothermic effects of ethanol in BXD/Ty recombinant inbred mice: genetic correlations and quantitative trait loci.

@article{Crabbe1996CommonGD,
  title={Common genetic determinants of the ataxic and hypothermic effects of ethanol in BXD/Ty recombinant inbred mice: genetic correlations and quantitative trait loci.},
  author={J Christopher F Crabbe and Tamara J Phillips and Edward J. Gallaher and Larry I. Crawshaw and Sean R. Mitchell},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1996},
  volume={277 2},
  pages={624-32}
}
Sensitivity and tolerance to ethanol-induced ataxia and hypothermia are determined in part by genetic factors; some genes that affect one of these traits may affect others as well. To test this general hypothesis, we examined hypothermia and two tests of ataxia in the C57BL/6J and DBA/2J inbred mouse stains and in 18 to 25 of their recombinant inbred strains. Genetic correlations among strain mean responses revealed strong positive associations of genetic origin between sensitivity and… CONTINUE READING

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