Common features of T cell reactivity in persistent helminth infections: lymphatic filariasis and schistosomiasis.

@article{Yazdanbakhsh1999CommonFO,
  title={Common features of T cell reactivity in persistent helminth infections: lymphatic filariasis and schistosomiasis.},
  author={Maria Yazdanbakhsh},
  journal={Immunology letters},
  year={1999},
  volume={65 1-2},
  pages={
          109-15
        }
}
This review highlights striking similarities in the down-regulated inflammatory responses that are observed in chronic infectious diseases. It is clear that peripheral mononuclear cells show poor antigen-specific T cell proliferation in lymphatic filariasis as well as schistosomiasis. With respect to cytokines both Th1- and Th2-type products are down-regulated during chronic infection. Drug treatment restores responsiveness in both diseases indicating a link between infection and immune… CONTINUE READING

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