Common features in DNA recognition helices of eukaryotic transcription factors.

@article{Suzuki1993CommonFI,
  title={Common features in DNA recognition helices of eukaryotic transcription factors.},
  author={Mamie Suzuki},
  journal={The EMBO journal},
  year={1993},
  volume={12 8},
  pages={3221-6}
}
Eukaryotic transcription factors which use an alpha-helix for DNA recognition, including the leucine zipper and homoeo domain proteins, have common features in the amino acid sequence of the DNA recognition helix, and also in the way this helix interacts with DNA. These factors all share a similar 12 residue segment in the DNA recognition helix, which is named the probe helix, since it covers all the pertinent interactions. Moreover, in all cases the interactions can be divided into two parts… CONTINUE READING