Common extracellular sensory domains in transmembrane receptors for diverse signal transduction pathways in bacteria and archaea.

@article{Zhulin2003CommonES,
  title={Common extracellular sensory domains in transmembrane receptors for diverse signal transduction pathways in bacteria and archaea.},
  author={Igor B. Zhulin and Anastasia N. Nikolskaya and Michael Y. Galperin},
  journal={Journal of bacteriology},
  year={2003},
  volume={185 1},
  pages={285-94}
}
Transmembrane receptors in microorganisms, such as sensory histidine kinases and methyl-accepting chemotaxis proteins, are molecular devices for monitoring environmental changes. We report here that sensory domain sharing is widespread among different classes of transmembrane receptors. We have identified two novel conserved extracellular sensory domains, named CHASE2 and CHASE3, that are found in at least four classes of transmembrane receptors: histidine kinases, adenylate cyclases, predicted… CONTINUE READING