Common expression of stemness molecular markers and early cardiac transcription factors in human Wharton's jelly-derived mesenchymal stem cells and embryonic stem cells.

@article{Gao2013CommonEO,
  title={Common expression of stemness molecular markers and early cardiac transcription factors in human Wharton's jelly-derived mesenchymal stem cells and embryonic stem cells.},
  author={Lian-ru Gao and Ning Zhang and Qing Ai Ding and Hai Yue Chen and Xiang Hu and S. Jiang and Tian C Li and Yan Chen and Zhi Guo Wang and Yang Ye and Zhi Ming Zhu},
  journal={Cell transplantation},
  year={2013},
  volume={22 10},
  pages={1883-900}
}
At present, there are still significant barriers that impede the clinical use of hESCs and iPS cells, including ethics, immunorejection, tumorigenesis from hESCs, and teratoma formation from iPS cells. It is therefore necessary to search for alternative sources of stem cells. WJ-MSCs originate from embryonic epiblasts and possess properties intermediate between hESCs and adult stem cells. However, the stemness properties of molecules in WJ-MSCs remain unclear compared to those of hESCs. In the… CONTINUE READING
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