Common deleted genes in the 5q− syndrome: thrombocytopenia and reduced erythroid colony formation in SPARC null mice

@article{Lehmann2007CommonDG,
  title={Common deleted genes in the 5q− syndrome: thrombocytopenia and reduced erythroid colony formation in SPARC null mice},
  author={S{\"o}ren Lehmann and J O'kelly and S. Raynaud and Sarah E Funk and Elizabeth Sage and H Phillip Koeffler},
  journal={Leukemia},
  year={2007},
  volume={21},
  pages={1931-1936}
}
The commonly deleted region (CDR) for the 5q− syndrome has been identified as a 1.5-megabase interval on human chromosome 5q32. We studied, by real-time reverse-transcription (RT)–PCR, the expression of 33 genes within the CDR that are known to be expressed in CD34+ hematopoietic stem cells. Genes in the 5q− samples that showed the most pronounced decrease in expression compared to non-5q− samples were: solute carrier family 36, member 1 (SLC36A1; 89% downregulated), Ras-GTPase-activating… CONTINUE READING

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