Common circuit defect of excitatory-inhibitory balance in mouse models of autism

@inproceedings{Gogolla2009CommonCD,
  title={Common circuit defect of excitatory-inhibitory balance in mouse models of autism},
  author={Nadine Gogolla and Jocelyn Jacqueline LeBlanc and Kathleen B. Quast and Thomas C S{\"u}dhof and Michela Fagiolini and Takao K Hensch},
  booktitle={Journal of Neurodevelopmental Disorders},
  year={2009}
}
One unifying explanation for the complexity of Autism Spectrum Disorders (ASD) may lie in the disruption of excitatory/inhibitory (E/I) circuit balance during critical periods of development. We examined whether Parvalbumin (PV)-positive inhibitory neurons, which normally drive experience-dependent circuit refinement (Hensch Nat Rev Neurosci 6:877–888, 1), are disrupted across heterogeneous ASD mouse models. We performed a meta-analysis of PV expression in previously published ASD mouse models… CONTINUE READING
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