Common biosynthetic origins for polycyclic tetramate macrolactams from phylogenetically diverse bacteria.

@article{Blodgett2010CommonBO,
  title={Common biosynthetic origins for polycyclic tetramate macrolactams from phylogenetically diverse bacteria.},
  author={Joshua A V Blodgett and Dong-Chan Oh and Shugeng Cao and Cameron R. Currie and Roberto Kolter and Jon Clardy},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 26},
  pages={11692-7}
}
A combination of small molecule chemistry, biosynthetic analysis, and genome mining has revealed the unexpected conservation of polycyclic tetramate macrolactam biosynthetic loci in diverse bacteria. Initially our chemical analysis of a Streptomyces strain associated with the southern pine beetle led to the discovery of frontalamides A and B, two previously undescribed members of this antibiotic family. Genome analyses and genetic manipulation of the producing organism led to the identification… CONTINUE READING

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