Common angiotensin receptor blockers may directly modulate the immune system via VDR, PPAR and CCR2b

@article{Marshall2005CommonAR,
  title={Common angiotensin receptor blockers may directly modulate the immune system via VDR, PPAR and CCR2b},
  author={Trevor Gordon Marshall and Robert Ellis Lee and Frances E. Marshall},
  journal={Theoretical Biology & Medical Modelling},
  year={2005},
  volume={3},
  pages={1 - 1}
}
There have been indications that common Angiotensin Receptor Blockers (ARBs) may be exerting anti-inflammatory actions by directly modulating the immune system. We decided to use molecular modelling to rapidly assess which of the potential targets might justify the expense of detailed laboratory validation. We first studied the VDR nuclear receptor, which is activated by the secosteroid hormone 1,25-dihydroxyvitamin-D. This receptor mediates the expression of regulators as ubiquitous as GnRH… CONTINUE READING
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