Common and selective molecular determinants involved in metabotopic glutamate receptor agonist activity.

@article{Bertrand2002CommonAS,
  title={Common and selective molecular determinants involved in metabotopic glutamate receptor agonist activity.},
  author={Hugues-Olivier Bertrand and A S Bessis and Jean-Philippe Pin and Francine C Acher},
  journal={Journal of medicinal chemistry},
  year={2002},
  volume={45 15},
  pages={3171-83}
}
Several potent and group selective agonists of metabotropic glutamate receptors (mGluRs) have been docked at mGlu1,2,4R binding sites in the closed conformation of the bilobate extracellular domain. Quisqualic acid and (S)-3,5-dihydroxyphenylglycine (3,5-DHPG) were selected for mGlu1R, dicarboxycyclopropylglycine (DCG-IV), LY354740, (S)-4-carboxyphenylglycine (4CPG) for mGlu2R, and (S)-2-amino-4-phosphonobutyric acid (AP4), 1-aminocyclopentane-1,3,4-tricarboxylic acid (ACPT-I), (S)-4… CONTINUE READING