Common and reversible regulation of wild-type p53 function and of ribosomal biogenesis by protein kinases in human cells

@article{DavidPfeuty2001CommonAR,
  title={Common and reversible regulation of wild-type p53 function and of ribosomal biogenesis by protein kinases in human cells},
  author={Th{\'e}rse David-Pfeuty and Yolande Nouvian-Dooghe and Valentina Sirri and Pascal Roussel and Danile Hernandez-Verdun},
  journal={Oncogene},
  year={2001},
  volume={20},
  pages={5951-5963}
}
Two specific inhibitors of cyclin-dependent kinase 2 (Cdk2), roscovitine and olomoucine, have been shown recently to induce nuclear accumulation of wt p53 and nucleolar unravelling in interphase human untransformed IMR-90 and breast tumor-derived MCF-7 cells. Here, we show that the early response of MCF-7 cells to roscovitine is fully reversible since a rapid restoration of nucleolar organization followed by an induction of p21WAF1/CIP1, a downregulation of nuclear wt p53 and normal cell cycle… CONTINUE READING

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