Common and rare variants in SCN10A modulate the risk of atrial fibrillation.

  title={Common and rare variants in SCN10A modulate the risk of atrial fibrillation.},
  author={Javad Jabbari and Morten Salling Olesen and Lei Yuan and Jonas Bille Nielsen and Bo Liang and Vincenzo S. Macri and Ingrid E Christophersen and Nikolaj B\orty Nielsen and Ahmad Sajadieh and Patrick T Ellinor and Morten Grunnet and Stig Hauns\o and Anders Gaarsdal Holst and Jesper Hastrup Svendsen and Thomas Jespersen},
  journal={Circulation. Cardiovascular genetics},
  volume={8 1},
BACKGROUND Genome-wide association studies have shown that the common single nucleotide polymorphism rs6800541 located in SCN10A, encoding the voltage-gated Nav1.8 sodium channel, is associated with PR-interval prolongation and atrial fibrillation (AF). Single nucleotide polymorphism rs6800541 is in high linkage disequilibrium with the nonsynonymous variant in SCN10A, rs6795970 (V1073A, r(2)=0.933). We therefore sought to determine whether common and rare SCN10A variants are associated with… CONTINUE READING
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