Common and rare variants associated with kidney stones and biochemical traits

@inproceedings{Oddsson2015CommonAR,
  title={Common and rare variants associated with kidney stones and biochemical traits},
  author={Asmundur Oddsson and Patrick Sulem and Hannes Helgason and Vidar Orn Edvardsson and Gudmar Thorleifsson and Gardar Sveinbj{\"o}rnsson and Eik Haraldsdottir and Gudmundur Ingi Eyjolfsson and Olof G Sigurdardottir and Ingvar Hakon Olafsson and Gisli M{\`a}sson and H. Spangsberg Holm and Daniel Fannar Gudbjartsson and Unnur Thorsteinsdottir and Olafur Sk{\'u}li Indridason and Runolfur Palsson and K{\'a}ri Stef{\'a}nsson},
  booktitle={Nature communications},
  year={2015}
}
Kidney stone disease is a complex disorder with a strong genetic component. We conducted a genome-wide association study of 28.3 million sequence variants detected through whole-genome sequencing of 2,636 Icelanders that were imputed into 5,419 kidney stone cases, including 2,172 cases with a history of recurrent kidney stones, and 279,870 controls. We identify sequence variants associating with kidney stones at ALPL (rs1256328[T], odds ratio (OR)=1.21, P=5.8 × 10(-10)) and a suggestive… CONTINUE READING
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