Common and rare alleles in apolipoprotein B contribute to plasma levels of low-density lipoprotein cholesterol in the general population.

@article{Benn2008CommonAR,
  title={Common and rare alleles in apolipoprotein B contribute to plasma levels of low-density lipoprotein cholesterol in the general population.},
  author={Marianne Benn and Maria Charlotte Stene and B\orge G. Nordestgaard and Gorm Boje Jensen and Rolf Steffensen and Anne Tybjaerg-Hansen},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2008},
  volume={93 3},
  pages={1038-45}
}
CONTEXT We have previously shown that rare mutations in the apolipoprotein B gene (APOB) may result in not only severe hypercholesterolemia and ischemic heart disease but also hypocholesterolemia. Despite this, common single-nucleotide polymorphisms (SNPs) in APOB have not convincingly been demonstrated to affect low-density lipoprotein (LDL) cholesterol levels. OBJECTIVE We tested the hypothesis that nonsynonymous SNPs in three important functional domains of APOB and APOB tag SNPs predict… CONTINUE READING
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