Common and differential pathophysiological features accompany comparable cognitive impairments in medication-free patients with schizophrenia and in healthy aging subjects.

@article{Dreher2012CommonAD,
  title={Common and differential pathophysiological features accompany comparable cognitive impairments in medication-free patients with schizophrenia and in healthy aging subjects.},
  author={Jean-Claude Dreher and Paul Koch and Philip Kohn and Jose Apud and Daniel R Weinberger and Karen Faith Berman},
  journal={Biological psychiatry},
  year={2012},
  volume={71 10},
  pages={890-7}
}
BACKGROUND Dysfunction of the dorsolateral prefrontal cortex (DLPFC) and parahippocampal region along with poor working memory are common neurophysiological and behavioral features associated with schizophrenia and normal aging. It is, however, unknown whether the associated patterns of neural activation differ between these two groups when their cognitive performance is closely matched in a pairwise manner. The authors sought to pinpoint common and differential pathophysiological features that… CONTINUE READING
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