Common alleles in candidate susceptibility genes associated with risk and development of epithelial ovarian cancer.

@article{Notaridou2011CommonAI,
  title={Common alleles in candidate susceptibility genes associated with risk and development of epithelial ovarian cancer.},
  author={Maria Notaridou and L. A. N. Quaye and Dimitra Dafou and Chris K Jones and Honglin Song and Estrid V. S. H\ogdall and Susanne Kr{\"u}ger Kjaer and Lise Christensen and Claus Kim H\ogdall and Jan Blaakaer and Valerie A McGuire and Anna H Wu and David Van Den Berg and Malcolm C. Pike and Aleksandra Gentry-Maharaj and Eva L Wozniak and Tanya Sher and Ian J. Jacobs and Jonathan P. Tyrer and Joellen Martha Schildkraut and Patricia G. Moorman and Edwin S. Iversen and Anna Jakubowska and Krzysztof Mędrek and Jan A. Lubiński and Roberta B. Ness and Kirsten B Moysich and Galina Lurie and Lynne Ross Wilkens and Michael E. Carney and Shan Wang-gohrke and Jennifer A Doherty and Mary Anne Rossing and Matthias W. Beckmann and Falk Clemens Thiel and Arif B. Ekici and Xiao-qing Chen and Jonathan Beesley and Jacek Gronwald and Peter A. Fasching and Jenny Chang-Claude and Marc T. Goodman and Georgia Chenevix-Trench and Andrew Berchuck and Celeste Leigh Pearce and Alice S. Whittemore and Usha Menon and Paul P. D. Pharoah and Simon A. Gayther and Susan J Ramus},
  journal={International journal of cancer},
  year={2011},
  volume={128 9},
  pages={2063-74}
}
Common germline genetic variation in the population is associated with susceptibility to epithelial ovarian cancer. Microcell-mediated chromosome transfer and expression microarray analysis identified nine genes associated with functional suppression of tumorogenicity in ovarian cancer cell lines; AIFM2, AKTIP, AXIN2, CASP5, FILIP1L, RBBP8, RGC32, RUVBL1 and STAG3. Sixty-three tagging single nucleotide polymorphisms (tSNPs) in these genes were genotyped in 1,799 invasive ovarian cancer cases… CONTINUE READING