Common Variants in MAGI2 Gene Are Associated with Increased Risk for Cognitive Impairment in Schizophrenic Patients

@inproceedings{Koide2012CommonVI,
  title={Common Variants in MAGI2 Gene Are Associated with Increased Risk for Cognitive Impairment in Schizophrenic Patients},
  author={Takayoshi Koide and Masahiro Banno and Branko Aleksic and Saori Yamashita and Tsutomu Kikuchi and Kunihiro Kohmura and Yasunori Adachi and Naoko Kawano and Itaru Kushima and Yukako Nakamura and Takashi Okada and M Ikeda and Kazutaka Ohi and Yuka Yasuda and Ryota Hashimoto and Toshiya Inada and Hiroshi Ujike and Tetsuya Iidaka and Michio Suzuki and Masatoshi Takeda and Nakao Iwata and Norio Ozaki},
  booktitle={PloS one},
  year={2012}
}
Schizophrenia is a complex psychiatric disorder characterized by positive symptoms, negative symptoms, and cognitive impairment. MAGI2, a relatively large gene (∼1.5 Mbps) that maps to chromosome 7q21, is involved in recruitment of neurotransmitter receptors such as AMPA- and NMDA-type glutamate receptors. A genetic association study designed to evaluate the association between MAGI2 and cognitive performance or schizophrenia has not been conducted. In this case-control study, we examined the… CONTINUE READING

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