Common SNPs explain some of the variation in the personality dimensions of neuroticism and extraversion

@inproceedings{Vinkhuyzen2012CommonSE,
  title={Common SNPs explain some of the variation in the personality dimensions of neuroticism and extraversion},
  author={Anna A. E. Vinkhuyzen and Nancy L Pedersen and Jian Yang and Sang Hong Lee and Patrik Karl Erik Magnusson and William G. Iacono and Matt McGue and Pamela A. F. Madden and A Christopher Heath and Michelle Luciano and A. M. Payton and Mike Horan and William E. R. Ollier and Neil Pendleton and Ian J. Deary and Grant W. Montgomery and Nicholas G. Martin and Peter M. Visscher and Naomi R Wray},
  booktitle={Translational Psychiatry},
  year={2012}
}
The personality traits of neuroticism and extraversion are predictive of a number of social and behavioural outcomes and psychiatric disorders. Twin and family studies have reported moderate heritability estimates for both traits. Few associations have been reported between genetic variants and neuroticism/extraversion, but hardly any have been replicated. Moreover, the ones that have been replicated explain only a small proportion of the heritability (<∼2%). Using genome-wide single-nucleotide… CONTINUE READING