Common Neural Substrates for the Addictive Properties of Nicotine and Cocaine

@article{Pich1997CommonNS,
  title={Common Neural Substrates for the Addictive Properties of Nicotine and Cocaine},
  author={Emilio Merlo Pich and Sonia R. Pagliusi and Michela A. Tessari and Dominique Talabot-Ayer and Rob Hooft van Huijsduijnen and Christian Chiamulera},
  journal={Science},
  year={1997},
  volume={275},
  pages={83 - 86}
}
Regional brain activation was assessed by mapping of Fos-related protein expression in rats trained to self-administration of intravenous nicotine and cocaine. Both drugs produced specific overlapping patterns of activation in the shell and the core of the nucleus accumbens, medial prefrontal cortex, and medial caudate areas, but not in the amygdala. Thus, the reinforcing properties of cocaine and nicotine map on selected structures of the terminal fields of the mesocorticolimbic dopamine… Expand
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This manuscript describes the use of one particular paradigm, a model in which work is done by laboratory animals to obtain intravenous infusions of nicotine, which is particularly useful for examining the mechanisms in the brain that are responsible for the maintenance of drug-taking behavior. Expand
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Cigarette smoking is the most widespread form of drug abuse due to the addictive properties of nicotine present in tobacco. Via binding to specific receptors, known as nicotinic acetylcholineExpand
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The results demonstrate that nicotine shares with highly addictive drugs a distinct neurochemical and functional consequence that contribute to the neurochemical definition of the addictive nature of nicotine. Expand
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