Common Neural Substrates for the Addictive Properties of Nicotine and Cocaine

@article{Pich1997CommonNS,
  title={Common Neural Substrates for the Addictive Properties of Nicotine and Cocaine},
  author={E. M. Pich and S. Pagliusi and M. Tessari and D. Talabot-Ayer and Rob Hooft van Huijsduijnen and Christian Chiamulera},
  journal={Science},
  year={1997},
  volume={275},
  pages={83 - 86}
}
  • E. M. Pich, S. Pagliusi, +3 authors Christian Chiamulera
  • Published 1997
  • Chemistry, Medicine
  • Science
  • Regional brain activation was assessed by mapping of Fos-related protein expression in rats trained to self-administration of intravenous nicotine and cocaine. Both drugs produced specific overlapping patterns of activation in the shell and the core of the nucleus accumbens, medial prefrontal cortex, and medial caudate areas, but not in the amygdala. Thus, the reinforcing properties of cocaine and nicotine map on selected structures of the terminal fields of the mesocorticolimbic dopamine… CONTINUE READING
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    • 155
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    References

    SHOWING 1-10 OF 13 REFERENCES
    Cortical dopaminergic involvement in cocaine reinforcement.
    • 494
    Acute nicotine injections induce c-fos mostly in non-dopaminergic neurons of the midbrain of the rat.
    • 54
    Cocaine induces striatal c-fos-immunoreactive proteins via dopaminergic D1 receptors.
    • 488
    • PDF
    Chronic injections of saline produce subsensitivity to nicotine
    • 24