Common Genetic Variation near MC4R Has a Sex-Specific Impact on Human Brain Structure and Eating Behavior

@inproceedings{Horstmann2013CommonGV,
  title={Common Genetic Variation near MC4R Has a Sex-Specific Impact on Human Brain Structure and Eating Behavior},
  author={Annette Horstmann and Peter Kovacs and Stefan Kabisch and Yvonne Boettcher and Haiko Schloegl and Anke Toenjes and Michael Stumvoll and Burkhard Pleger and Arno Villringer},
  booktitle={PloS one},
  year={2013}
}
Obesity is associated with genetic and environmental factors but the underlying mechanisms remain poorly understood. Recent genome-wide association studies (GWAS) identified obesity- and type 2 diabetes-associated genetic variants located within or near genes that modulate brain activity and development. Among the top hits is rs17782313 near MC4R, encoding for the melanocortin-4-receptor, which is expressed in brain regions that regulate eating. Here, we hypothesized rs17782313-associated… CONTINUE READING
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