Common Genetic Variation in the Human FNDC5 Locus, Encoding the Novel Muscle-Derived ‘Browning’ Factor Irisin, Determines Insulin Sensitivity

@inproceedings{Staiger2013CommonGV,
  title={Common Genetic Variation in the Human FNDC5 Locus, Encoding the Novel Muscle-Derived ‘Browning’ Factor Irisin, Determines Insulin Sensitivity},
  author={Harald Staiger and Anja B{\"o}hm and Mika Scheler and Lucia Berti and J{\"u}rgen Machann and Fritz Schick and Fausto Machicao and Andreas Fritsche and Norbert Stefan and Cora Weigert and Anna Krook and Hans-Ulrich H{\"a}ring and Martin Hrabe de Angelis},
  booktitle={PloS one},
  year={2013}
}
AIMS/HYPOTHESIS Recently, the novel myokine irisin was described to drive adipose tissue 'browning', to increase energy expenditure, and to improve obesity and insulin resistance in high fat-fed mice. Here, we assessed whether common single nucleotide polymorphisms (SNPs) in the FNDC5 locus, encoding the irisin precursor, contribute to human prediabetic phenotypes (overweight, glucose intolerance, insulin resistance, impaired insulin release). METHODS A population of 1,976 individuals was… CONTINUE READING

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Here , we assessed whether common single nucleotide polymorphisms ( SNPs ) in the FNDC5 locus , encoding the irisin precursor , contribute to human prediabetic phenotypes ( overweight , glucose intolerance , insulin resistance , impaired insulin release ) . METHODS .
Here , we assessed whether common single nucleotide polymorphisms ( SNPs ) in the FNDC5 locus , encoding the irisin precursor , contribute to human prediabetic phenotypes ( overweight , glucose intolerance , insulin resistance , impaired insulin release ) . METHODS .
Here , we assessed whether common single nucleotide polymorphisms ( SNPs ) in the FNDC5 locus , encoding the irisin precursor , contribute to human prediabetic phenotypes ( overweight , glucose intolerance , insulin resistance , impaired insulin release ) . METHODS .
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