Common Genetic Variation in the Human FNDC5 Locus, Encoding the Novel Muscle-Derived ‘Browning’ Factor Irisin, Determines Insulin Sensitivity

@article{Staiger2013CommonGV,
  title={Common Genetic Variation in the Human FNDC5 Locus, Encoding the Novel Muscle-Derived ‘Browning’ Factor Irisin, Determines Insulin Sensitivity},
  author={Harald Staiger and Anja B{\"o}hm and Mika Scheler and Lucia Berti and J{\"u}rgen Machann and Fritz Schick and Fausto Machicao and Andreas Fritsche and Norbert Stefan and Cora Weigert and Anna Krook and Hans-Ulrich H{\"a}ring and Martin Hrabě de Angelis},
  journal={PLoS ONE},
  year={2013},
  volume={8}
}
  • Harald Staiger, Anja Böhm, +10 authors Martin Hrabě de Angelis
  • Published 2013
  • Biology, Medicine
  • PLoS ONE
  • Aims/hypothesis Recently, the novel myokine irisin was described to drive adipose tissue ‘browning’, to increase energy expenditure, and to improve obesity and insulin resistance in high fat-fed mice. Here, we assessed whether common single nucleotide polymorphisms (SNPs) in the FNDC5 locus, encoding the irisin precursor, contribute to human prediabetic phenotypes (overweight, glucose intolerance, insulin resistance, impaired insulin release). Methods A population of 1,976 individuals was… CONTINUE READING

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 79 CITATIONS, ESTIMATED 38% COVERAGE

    Fibronectin Type III Domain–Containing Protein 5 rs3480 A>G Polymorphism, Irisin, and Liver Fibrosis in Patients With Nonalcoholic Fatty Liver Disease

    VIEW 5 EXCERPTS
    CITES BACKGROUND & RESULTS
    HIGHLY INFLUENCED

    FILTER CITATIONS BY YEAR

    2013
    2020

    CITATION STATISTICS

    • 5 Highly Influenced Citations

    • Averaged 7 Citations per year from 2018 through 2020

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 40 REFERENCES