Common Genetic Variants and Gene-Expression Changes Associated with Bipolar Disorder Are Over-Represented in Brain Signaling Pathway Genes

@article{Pedroso2012CommonGV,
  title={Common Genetic Variants and Gene-Expression Changes Associated with Bipolar Disorder Are Over-Represented in Brain Signaling Pathway Genes},
  author={I. Pedroso and A. Lourdusamy and M. Rietschel and M. N{\"o}then and S. Cichon and P. McGuffin and A. Al-Chalabi and M. Barnes and G. Breen},
  journal={Biological Psychiatry},
  year={2012},
  volume={72},
  pages={311-317}
}
BACKGROUND Despite high heritability, the genetic variants influencing bipolar disorder (BD) susceptibility remain largely unknown. Low statistical power to detect the small effect-size alleles believed to underlie much of the genetic risk and possible heterogeneity between cohorts are an increasing concern. Integrative biology approaches might offer advantages over genetic analysis alone by combining different genomic datasets at the higher level of biological processes rather than the level… Expand
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