Common Genetic Determinants of Lung Function, Subclinical Atherosclerosis and Risk of Coronary Artery Disease

@inproceedings{SabaterLleal2014CommonGD,
  title={Common Genetic Determinants of Lung Function, Subclinical Atherosclerosis and Risk of Coronary Artery Disease},
  author={Maria Sabater-Lleal and Anders M{\"a}larstig and Lasse Folkersen and Mar{\'i}a Soler Artigas and Damiano Baldassarre and Maryam Kavousi and Peter Almgren and Fabrizio Veglia and Guy Brusselle and Albert Hofman and Gunnar Engstr{\"o}m and Oscar H Franco and Olle Melander and Gabrielle Paulsson-Berne and H. P. Watkins and Per Eriksson and Steve E Humphries and Elena Tremoli and Ulf de Faire and Martin D Tobin and Anders Hamsten},
  booktitle={PloS one},
  year={2014}
}
Chronic obstructive pulmonary disease (COPD) independently associates with an increased risk of coronary artery disease (CAD), but it has not been fully investigated whether this co-morbidity involves shared pathophysiological mechanisms. To identify potential common pathways across the two diseases, we tested all recently published single nucleotide polymorphisms (SNPs) associated with human lung function (spirometry) for association with carotid intima-media thickness (cIMT) in 3,378 subjects… CONTINUE READING

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