Common Developmental Requirement for Olig Function Indicates a Motor Neuron/Oligodendrocyte Connection

  title={Common Developmental Requirement for Olig Function Indicates a Motor Neuron/Oligodendrocyte Connection},
  author={Q.Richard Lu and Tao Sun and Zhimin Zhu and Nan Ma and Meritxell de Jes{\'u}s Garc{\'i}a and Charles Dean Stiles and David H Rowitch},
The oligodendrocyte lineage genes Olig1 and Olig2 encode related bHLH proteins that are coexpressed in neural progenitors. Targeted disruption of these two genes sheds light on the ontogeny of oligodendroglia and genetic requirements for their development from multipotent CNS progenitors. Olig2 is required for oligodendrocyte and motor neuron specification in the spinal cord. Olig1 has roles in development and maturation of oligodendrocytes, evident especially within the brain. Both Olig genes… CONTINUE READING
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